Sunday, April 11, 2010

vitamin e/beta carotene may increase cvd

A systematic review of antioxidants for primary prevention of cardiovascular disease identified four RCTs of vitamin E; the review found no benefits for vitamin E [1). One of the RCTs identified in the review found that vitamin E may increase death from subarachnoid hemorrhage [2). The review also identified six RCTs of beta-carotene; the review found no benefit for beta-carotene. Pooled analysis of four of these six RCTs found that beta-carotene may increase cv mortality
References
Asplund K (2002) Antioxidant vitamins in the prevention of cardiovascular disease: A systematic review. J Intern Med 251:372–392.
Lepp�l� JM, Virtamo J, Fogelholm R, Huttunen JK, Albanes D, et al. (2000) Controlled trial of alpha-tocopherol and beta-carotene supplements on stroke incidence and mortality in male smokers. Arterioscler Thromb Vasc Biol 20:230–235.
Egger M, Schneider M, Davey Smith G (1998) Spurious precision? Meta-analysis of observational studies. BMJ 316:140–144.
Doering WV (1996) Antioxidant vitamins, cancer, and cardiovascular disease. N Engl J Med 335:1065.
Pietrzik K (1996) Antioxidant vitamins, cancer, and cardiovascular disease. N Engl J Med 335:1065–1066.

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